A single-chain antibody generation system yielding CAR-T cells with superior antitumor function
نویسندگان
چکیده
منابع مشابه
Generation and Characterization of a Single Gene-encoded Single- Chain-Tetravalent Antitumor Antibody I
Monoclonal antibody (mAb) CC49, a murine IgG1, reacts with the tumor-associated glycoprotein-72 expressed on a variety of carcinomas. In clinical trials, radiolabeled CC49 has shown excellent tumor localization to a variety of carcinomas. To minimize the immunogenicity of CC49 mAb in patients, a humanized CC49 (HuCC49) was generated by complementarity-determining region (CDR) grafting. The rela...
متن کاملGeneration and characterization of a single gene-encoded single-chain-tetravalent antitumor antibody.
Monoclonal antibody (mAb) CC49, a murine IgG1, reacts with the tumor-associated glycoprotein-72 expressed on a variety of carcinomas. In clinical trials, radiolabeled CC49 has shown excellent tumor localization to a variety of carcinomas. To minimize the immunogenicity of CC49 mAb in patients, a humanized CC49 (HuCC49) was generated by complementarity-determining region (CDR) grafting. The rela...
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Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...
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ژورنال
عنوان ژورنال: Communications Biology
سال: 2021
ISSN: 2399-3642
DOI: 10.1038/s42003-021-01791-1